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Abbreviations ALADIN a long-acting somatostatin on disease progression in nephropathy due to PKD AC adenylyl cyclase AMPK AMP activated protein kinase AREG amphiregulin ADA anti-drug antibody anti-miR anti-micro RNA AQ1 aquaporin 1 ANN artificial neural network methods ADPKD autosomal dominant polycystic kidney disease ARPKD autosomal recessive polycystic kidney disease BNP B type natriuretic peptide AC-VI calcium-inhibitable adenylyl cyclase 6 cIAP1 cellular inhibitor of apoptosis protein 1 CRISPR clustered regularly interspaced short palindromic repeats CCD cortical collecting ducts cAMP cyclic adenosine monophosphate cGMP cyclic GMP CFTR cystic fibrosis transmembrane conductance regulator DZIP1L DAZ interacting zinc finger protein 1 ELP elastin-like polypeptide ER endoplasmic reticulum ESRD end-stage renal disease ELISA enzyme-linked immunosorbent assay EGFR epidermal growth factor receptors eGFR estimated glomerular filtration rate ERK extracellular signal-regulated kinase FLIP Fas-associated death domain-like interleukin-1-beta-converting enzyme-inhibitory protein long form FDA Food and Drug Administration GFR glomerular filtration rate GSK3β glycogen synthase kinase 3 β HB-EGF heparin-binding epidermal growth factor KTP kidney targeting peptide LAR long-acting release mTOR mammalian target of rapamycin MAPK mitogen-activated protein kinases pathway PDE phosphodiesterase PI3K/AKT/mTOR phosphoinositide 3-kinases, protein kinase B, mammalian target of rapamycin PKHD1 polycystic kidney and hepatic disease 1 PKD polycystic kidney disease PC polycystin complex PC1 polycystin-1 PC2 polycystin-2 PKA protein kinase A PCT proximal convoluted tubules PCK rat rat model of polycystic kidney disease Ras rat sarcoma RIPK1 receptor interacting serine/threonine kinase 1 RAS renin angiotensin aldosterone system S6K S6 kinase Src sarcoma SPAR small regulatory polypeptide of amino acid response SPPS solid phase peptide synthesis SVM support vector machine SPR surface plasmon resonance TEMPO tolvaptan efficacy and safety in management of autosomal dominant polycystic kidney disease and its outcomes TKV total kidney volume TKW/BW total kidney weight per body weight Tat-1 transactivator of transcription 1 TALEN transcription activator-like effector nucleases TGF-α transforming growth factor-α TSC1 tuberous sclerosis complex protein 1 TSC2 tuberous sclerosis complex protein 2 TNFα tumor necrosis factor α V2R vasopressin receptor VEGF vessel endothelial growth factor B-Raf v-raf murine sarcoma viral oncogene homolog B Wnt wingless integration 1 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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These internal herbal remedies offer a holistic approach to managing hemorrhoids by addressing dietary and digestive aspects that contribute to symptom relief