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Indirect Mechanisms: Potential Pathways to Weight Influence While direct evidence supporting BPC-157's role in weight loss is scarce, some indirect mechanisms may be at play

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Hemizygosity in HIF1a prevents enhanced neurogenesis following IH EARLY but not IH LATE While hippocampal HIF1a appears to drive ROS production by IH 22 , cell-autonomous HIF1a signaling in neural precursors can also serve as a pro-neurogenesis factor 34,48,49