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doi: 10.3164/jcbn.17-137 171 NarneP.PhanithiP

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This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gut–brain axis (Joo et al., 2023)