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Similarly, the placebo-controlled study on efficacy and safety of N -acetylcysteine high dose in exacerbations of chronic obstructive pulmonary disease held (PANTHEON) with 1006 patients with moderate and severe COPD, treated with 1200 mg of oral NAC per day, resulted in a significant reduction in acute exacerbations of COPD in the treated group compared to the placebo group, especially in patients with moderate disease [54]