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This effect has also been found to be dependent on phospho-akt (p-akt) activation and inhibition of p38 mitogen-activated protein kinase (MAPK) (Zhang et al., 2013a), and is often associated with inhibition of vascular mitogenic activity (Qin et al., 2008), both of which have been experimentally verified in vitro and in vivo (Zhang et al., 2019)

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No negative side effects and hasn’t worn off days after