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As with allopurinol, it is reasonable whenever possible to add a preventative medication, such as colchicine, for at least the first six months after starting febuxostat to help avoid gout flares

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455 Signaling pathway-associated crosstalk Various studies have shown that no pathway exists independently, and direct regulation or mutual influence between signaling pathways and targets can enable cells to integrate different environmental signals and make more precise responses to meet the overall needs of the body