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Previous IGF-1 LR3 direct infusion studies into normally grown fetal sheep showed an infusion rate of 6.6 µg·kg −1 ·h −1 based on an estimated fetal weight of 3.5 kg resulting in increased organ weights and lower insulin concentrations (20, 24–26, 38)

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View on PubMed [PubMed] Effects of Human Growth Hormone in Men over 60 Years Old (NEJM, 1990) Landmark New England Journal of Medicine clinical study demonstrating that GH administration in men over 60 with low IGF-1 levels reversed body composition changes associated with aging: lean body mass increased, adipose tissue mass decreased, and skin thickness improved over six months