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Consistent with the importance of GSH in hepatic fibrogenesis, we found that a lower hepatic GSH level greatly potentiated BDL-induced fibrosis and if induction in GCLC expression was blocked (by using RNAi), the therapeutic efficacy of UDCA and SAMe was nearly lost [174]

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doi: 10.3329/bmrcb.v35i1.2132 65 Alvarez-ParrillaEde la RosaLALegarretaPSaenzLRodrigo-GarciaJGonzalez-AguilarGA