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Nicotinamide is the substrate for NAD+ salvage through NAMPT, so methylating it diverts material from that route

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NLRC5 senses NAD(+) depletion, forming a PANoptosome and driving PANoptosis and… [PMID: 38878777] Laboratory literature summary: NLRC5 senses NAD(+) depletion, forming a PANoptosome and driving PANoptosis and inflammation