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Oxidants and Antioxidants | Journal of The COPD Foundation
High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance
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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters — establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
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