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Metformin, via the AMPK/ACC pathway, reshapes lipid utilization and reduces ACSL4 and 4-HNE positivity, thereby improving chondrocyte resistance to ferroptosis (74)

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While preventive vaccination has limited impact on reducing hepatitis B burden (Yuan et al., 2022), nucleotide analogs and antiviral drugs have shown efficacy in treatment, although they may not completely eliminate the risk of HCC development (Roade et al., 2021)