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In another study conducted to investigate the anti-nociceptive and anti-inflammatory effect of riboflavin in animal models of hyperalgesia and inflammation, it was found that this vitamin can be effective in dose range of 6.25 to 150 mg/kg/day and competed with gabapentin.[10] Moreover, experiments in animals have shown that vitamins B1, B6, and B12 alone and in combination have anti-nociceptive activity against chemical- and heat-induced pain.[15,37] In a study conducted by Hosseinzadeh et al