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The majority of GSH studies (N = 5, 71%) reported significantly lower plasma levels with increasing age in adults (18–85 yrs) (Jones et al., 2002), as well as in old adults relative to (a) young adults by the majority of studies (2/3, 67%) (Giustarini et al., 2006, Yang et al., 1995), and (b) young to middle-aged adults in two studies (Maciejczyk et al., 2019, Samiec et al., 1998)