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A B12 deficiency can also be responsible for depressive episodes, anxiety disorders and mood swings and can lead to inflammation and ulcers throughout the digestive tract – starting in the mouth with aphthae and inflammation of the tongue (so-called Hunter’s glossitis)

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The choice depends on the type of pain, MRI findings, urgency of pain relief, age, medical risk, previous treatments, and whether the main goal is rapid pain control, lower numbness risk, diagnostic clarification, or long-term neuromodulation