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One at p K aeff = 1.7 makes b-[H10A24] more resistant to changes in the protonation state of the heme in both the oxidized and reduced states than in b-[Δ7-His] with p K aeff = 5.7

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Two phase 3 trials BLOOM (Behavioral modification and Lorcaserin for Overweight and Obesity Management) and BLOSSOM (Behavioral modification and LOrcaserin Second Study for Obesity Management) evaluated obese and overweight patients to demonstrate the efficacy of lorcaserin (10 mg twice daily) over placebo [83.84]