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What the general enforcement pattern looks like in this space: - **FDA warning letters** to manufacturers and distributors making drug claims about unapproved substances (claims like "promotes wound healing" or "stimulates collagen production" for a therapeutic purpose) - **Import alerts** that allow FDA to detain shipments of unapproved drug products at the border without physical examination - **483 inspection observations** and consent decrees against compounding pharmacies found to be producing unapproved substances - **FTC enforcement** against companies making unsubstantiated health claims in advertising The FDA's enforcement posture on research peptides has tightened meaningfully since 2020

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doi: 10.3390/md21030176