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Clinical Evidence: What Research Shows About GLP-1 Medications and Menstrual Health Clinical trials of semaglutide and tirzepatide reported menstrual irregularities in roughly 5–15% of female participants, with most cases occurring during the first three months of treatment

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In practice, many patients try to address parts of this problem on their own — through diet changes , supplements (vitamin D, magnesium), physiotherapy , or different medications