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Bearing these significant caveats in mind, it is probably premature to take a firm stance on how GAD expression is regulated in depressed patients, and how this may or may not be relevant to the observed reductions in GABA concentration

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Evidence from multiple fields, including metabolism, cell biology, and clinical endocrinology, collectively suggests that within the uterine fibroid microenvironment, E 2 and progesterone may induce excessive ROS accumulation through three pathways: enzyme metabolic imbalance, mitochondrial dysfunction, and disruption of the antioxidant system