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A 2025 NIH pilot study (n=300) observed headaches in 4% of injection recipients, lasting 5,000 mcg/day or injections during anemia correction), affecting 0.2-0.5% of patients

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[DOI] [PubMed] [Google Scholar] Kaufmann FN, Costa AP, Ghisleni G, Diaz AP, Rodrigues ALS, Peluffo H, Kaster MP (2017) NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings