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Notably, activated T cells secrete IFN-γ, which further downregulates the expression of SLC7A11 and SLC3A2, fostering a self-amplifying loop of ferroptosis (Wang et al., 2024)

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The PREDIMED trial, which enrolled thousands of older adults at cardiovascular risk, demonstrated that MD adherence may improve memory and executive function and potentially delayed progression to mild cognitive impairment (204)

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