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The study’s authors noted that increases in GH and IGF-I levels produced by CJC-1295 DAC were “dose-dependent,” meaning that in the context of that particular study, higher doses of CJC-1295 produced greater rises in GH and IGF-1 levels than lower doses
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Secondly, under drug stress, the fungus undergoes core metabolic remodeling, with the activities of glycolysis and the tricarboxylic acid cycle being downregulated, and the cells entering a low metabolism and non-proliferative dormant state, significantly reducing their sensitivity to lethal doses of antifungal drugs