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5.3 Helminth-mediated changes to macrophages may alter the crosstalk with β-cells While the aforementioned studies clearly demonstrate a critical role for macrophages in the protective mechanisms of helminths against diabetes development, most reports simply concluded that the beneficial effects were attributable to a switch in the predominant inflammatory phenotype of macrophage

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S-adenosylhomocysteine inhibits NF-kappaB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity