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The result can be hollow cheeks, sunken temples, more visible under-eye hollows, thinner and looser skin, and early jowling

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( Anesthesiology, 2024 ) conducted a randomized, blinded trial in 120 patients undergoing foot or ankle surgery with popliteal sciatic + saphenous blocks and found that IV dexamethasone (12 mg) significantly prolonged block analgesia versus placebo (~56% increase), but adding IV dexmedetomidine (1 µg/kg) provided no additional prolongation