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Tirzepatide is an FDA-approved prescription medication marketed as Mounjaro for type 2 diabetes mellitus and Zepbound for chronic weight management in adults with BMI ≥30 kg/m², or ≥27 kg/m² with at least one weight-related comorbidity

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Ketamine, as the nasal spray esketamine, is approved for treatment-resistant depression, and psilocybin has shown lasting benefit after one or two sessions in depression trials