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Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Shalem et al., 2015)

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1 In addition, pituitary tumors associated with low gonadotropin production, such as prolactinomas (which produce high amounts of the hormone prolactin and can reduce production of other pituitary hormones), can cause infertility