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NO, in addition to its antiproliferative and vasorelaxing roles, has an important role in antagonizing the effects of endothelins, AT-II, and ROS.[35] Reduced NO levels can be attributed to elevated levels of ROS

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It is sometimes called the “universal antioxidant” because it is both water-soluble and fat-soluble, meaning it can work in every tissue and cell compartment in the body