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Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities - PMC

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Based on the ability of the Met cycle and transsulfuration pathway to supply reduced S to hepatic GSH pools, we hypothesized that hepatocytes in the TrxR1/Gsr-null livers obtained all of their Cys and all of their cytosolic disulfide reducing power from consumption of Met [107]