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The clinical trial is testing nivolumab alone and in combination with other anticancer drugs, including ipilimumab, in patients with dMMR or MSI-H metastatic colorectal cancer that had progressed after treatment with fluoropyrimidine- and oxaliplatin-containing chemotherapy or fluoropyrimidine- and irinotecan-containing chemotherapy

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Apoptosis is induced via two main routes involving either the mitochondria (the intrinsic pathway) or the activation of death receptors (the extrinsic pathway)