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It retains the stabilising amino-acid substitutions that protect against rapid degradation, but its action is short and pulsatile, with a half-life reported on the order of roughly 30 minutes

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For this reason, drugs with a long half-life (e.g., amiodarone, elimination t ⁠1/2⁠ of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly