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A quality control of the raw sequences produced by the instrument (technical quality control) was performed

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Our group synthesized a series of macrocyclic peptides with the aim to determine bioactive conformations and better understand the mode of binding and structural requirements for efficient binding of Ang IV to IRAP ( 15 encompassing an 11-membered macrocycle was more potent as an IRAP inhibitor than the native Ang IV and exhibited a Ki value of 26 nM (Figure 5)