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In the β3-KO and WT groups, male mice aged 12–14 weeks were divided into three subgroups including: saline control, AOD9604 administered at a dose of 250 µg/kg/day, and hGH administered at a dose of 1 mg/kg/day

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Multiple studies show reduced melanin index with oral supplementation — but effects are gradual (months of use), modest, and vary significantly between individuals