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Simultaneously, through its sulfhydryl group binding with free radicals in the body, GSH can directly reduce free radicals into acidic substances, thereby accelerating their excretion and counteracting the damage caused by free radicals to vital organs

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In vivo , obesity and insulin resistance in mice were associated with GPx-1 overexpression, further supporting a dual role for GPx-1 in regulating different types of oxidative stress with a possible deleterious impact on metabolism, molecular, and physiological functions