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This mirrors the loading-dose strategy used in some vitamin B12 deficiency protocols, where initial doses are given more frequently to replete stores before transitioning to maintenance (Andrès et al., Journal of Blood Medicine , 2018)

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Unscheduled DNA synthesis UDS, which represents DNA repair activity following excision of DNA damage, has been reported in rat hepatocytes (Williams et al., 1989b) and SHE cells (Hamaguchi and Tsutui, 2000) exposed to formaldehyde